BEHAVIOR OF IGG ANTIBODY AVIDITY FOR THE ANTIGEN AND OF IGA ANTIBODY IN ACTIVE CYTOMEGALOVIRUS, EPSTEIN-BARR-VIRUS, HERPES-SIMPLEX VIRUS AND HUMAN HERPES-VIRUS-6 INFECTIONS - ADAPTATION OF A COMMERCIAL TEST

Authors
GUTIERREZ J RODRIGUEZ M MAROTO MC PIEDROLA G PEIRON J
Citation
J. Gutierrez et al., BEHAVIOR OF IGG ANTIBODY AVIDITY FOR THE ANTIGEN AND OF IGA ANTIBODY IN ACTIVE CYTOMEGALOVIRUS, EPSTEIN-BARR-VIRUS, HERPES-SIMPLEX VIRUS AND HUMAN HERPES-VIRUS-6 INFECTIONS - ADAPTATION OF A COMMERCIAL TEST, The Journal of infection, 35(1), 1997, pp. 25-30
Citations number
30
Categorie Soggetti
Infectious Diseases
Journal title
The Journal of infection → ACNP
ISSN journal
01634453
Volume
35
Issue
1
Year of publication
1997
Pages
25 - 30
Database
ISI
SICI code
0163-4453(1997)35:1<25:BOIAAF>2.0.ZU;2-6
Abstract
The clinical value of specific IgA and IgG antibody avidity to herpes simplex virus, cytomegalovirus, Epstein-Barr virus and human herpes vi rus 6 for the detection of active disease and primary infection, respe ctively, was evaluated. The IgG avidity test, with a break point of 55 %, for the detection of primary infection, and of the IgA test for the detection of disease, were associated with a sensitivity of 97% and 6 4%, respectively; specificity of 100% and 82%; a positive predictive v alue of 100% and 76%; and a negative predictive value of 96% and 72%, respectively.