RELATION BETWEEN HELICOBACTER-PYLORI INFECTION AND GASTROINTESTINAL SYMPTOMS AND SYNDROMES

Background-Helicobacter pylori is a human pathogen that colonises the gastric mucosa and causes permanent gastric inflammation, Aims-To asse ss the symptoms of H pylori infection in an adult unselected populatio n. Subjects-A random sample of 3589 adult Danes who were examined in 1 982 and 1987 (n=2987). Methods-Abdominal symptoms within the preceding year were recorded at both attendances. Circulating IgG antibodies ag ainst H pylori in serum samples drawn in 1982 were measured by using i n-house indirect enzyme linked immunosorbent assays (ELISA). Results-P eople with increased levels of IgG antibodies to H pylori were more li kely than uninfected individuals to report heartburn (odds ratio (OR) = 1.26, 95% confidence interval (CI) 1.03-1.54) and abdominal pain cha racterised by daily length (OR = 1.33, 95% CI 0.92-1.91), nocturnal oc currence (OR = 1.62, 95% CI 1.19-2.19), spring aggravation (OR = 1.68, 95% CI 0.70-4.05), and no relation to meals (OR = 0.62, 95% CI 0.43-0 .91) or stress (OR = 0.69, 95% CI 0.50-0.95). The inclusion of people with increased levels of IgG antibodies to H pylori, but without upper dyspepsia, at study entry significantly increased the likelihood of r eporting, upper dyspepsia at follow up (OR = 1.71, 95% CI 1.24-2.36). People with epigastric pain and increased levels of IgM antibodies to H pylori only indicative of acute H pylori infection were more likely to report nocturnal pain, heartburn, nausea, and vomiting. Conclusions -H pylori infection may precede the development of dyspepsia and is as sociated with a variety of gastrointestinal symptoms in people with no history of peptic ulcer disease.