SEIZURES AND HEPATOTOXICITY FOLLOWING SULFASALAZINE ADMINISTRATION

Authors
SENTURK T AYDINTUG AO DUZGUN N TOKGOZ G
Citation
T. Senturk et al., SEIZURES AND HEPATOTOXICITY FOLLOWING SULFASALAZINE ADMINISTRATION, Rheumatology international, 17(2), 1997, pp. 75-77
Citations number
15
Categorie Soggetti
Rheumatology
Journal title
Rheumatology international → ACNP
ISSN journal
01728172
Volume
17
Issue
2
Year of publication
1997
Pages
75 - 77
Database
ISI
SICI code
0172-8172(1997)17:2<75:SAHFSA>2.0.ZU;2-X
Abstract
Sulphasalazine (SSZ) is a widely used second-line agent for several rh eumatic diseases. Most of its side effects are relatively minor and do se dependent. We report a patient with juvenile onset chronic arthriti s who developed hepatotoxicity and seizures on the third week of SSZ w hen the daily dose was increased to 2 g. Clinical and laboratory findi ngs of liver and central nervous system toxicity gradually returned to normal in the month following SSZ withdrawal.