EVIDENCE FOR THE INVOLVEMENT OF P-2-PURINOCEPTORS IN THE CHOLINERGIC CONTRACTION OF THE GUINEA-PIG ILEUM

Authors
BARTHO L LENARD L MAGGI CA
Citation
L. Bartho et al., EVIDENCE FOR THE INVOLVEMENT OF P-2-PURINOCEPTORS IN THE CHOLINERGIC CONTRACTION OF THE GUINEA-PIG ILEUM, British Journal of Pharmacology, 121(8), 1997, pp. 1507-1508
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
121
Issue
8
Year of publication
1997
Pages
1507 - 1508
Database
ISI
SICI code
0007-1188(1997)121:8<1507:EFTIOP>2.0.ZU;2-S
Abstract
In the isolated ileum of the guinea-pig the P-2-purinoceptor antagonis ts PPADS and suramin: (a) strongly inhibited the cholinergic contracti le effect of alpha,beta-methylene ATP, (b) did not influence contracti ons evoked by exogenous acetylcholine (ACh) but, (c) moderately (by ab out 30%) inhibited cholinergic contractions due to electrical field st imulation (EFS), in a non-additive manner. These results suggest that an endogenous ligand that stimulates P-2-purinoceptors (possibly ATP) is involved in the contractile effect of EFS, as a positive modulator of ACh release.