SYNTHETIC APPROACHES TO BENZOFURAN CONTAINING INSULIN SENSITIVITY ENHANCER COMPOUNDS FOR TREATMENT OF TYPE-II DIABETES

The search for Insulin Sensitivity Enhancer (ISE) compounds, for poten tial use in the treatment of Type II diabetes, has led to the synthesi s of compounds that contain a benzofuran spacer between an aryloyl sub stituent and a 2,4-thiazolidinedione pharmacophore. Sequential combina tion of haloacetyl aryl substrates with 5-formylsalicylaldehyde gave t he desired 2-aryloyl-5-formylbenzofuran intermediates. A related class of compounds, those with a methylene tether between the aromatic moie ty and the benzofuran spacer, were also prepared through this strategy .