CASPASES - KILLER PROTEASES

Authors
NICHOLSON DW THORNBERRY NA
Citation
Dw. Nicholson et Na. Thornberry, CASPASES - KILLER PROTEASES, Trends in biochemical sciences, 22(8), 1997, pp. 299-306
Citations number
57
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
8
Year of publication
1997
Pages
299 - 306
Database
ISI
SICI code
0968-0004(1997)22:8<299:C-KP>2.0.ZU;2-A
Abstract
Caspases (cysteinyl aspartate-specific proteinases) mediate highly spe cific proteolytic cleavage events in dying cells, which collectively m anifest the apoptotic phenotype. The key and central role that these e nzymes play in a biochemical cell-suicide pathway has been conserved t hroughout the evolution of multicellular eukaryotes.