To investigate the association between anthropometric indices and morp
hometrically determined vertebral deformity, the authors carried out a
cross-sectional study using data from the European Vertebral Osteopor
osis Study (EVOS), a population-based study of vertebral osteoporosis
in 36 European centers from 19 countries. A total of 16,047 EVOS subje
cts were included in this analysis, of whom 1,973 subjects (915 males,
1,058 females) (12.3%) aged 50 years or over had one or more vertebra
l deformities (''cases''). The cases were compared with the 14,074 sub
jects (6,539 males, 7,535 females) with morphometrically normal spines
(''controls''). Data were collected on self-reported height at age 25
years and minimum weight after age 25 years, as well as on current me
asured height and weight. Body mass index (BMI) and height and weight
change were calculated from these data. The relations between these va
riables and vertebral deformity were examined separately by sex with l
ogistic regression adjusting for age, smoking, and physical activity.
In females, there was a significant trend of decreasing risk with incr
easing quintile of current weight, current BMI, and weight gain since
age 25 years. In males, subjects in the lightest quintile for these me
asures were at increased risk but there was no evidence of a trend. An
ecologic analysis by country revealed a negative correlation between
mean BMI and the prevalence of deformity in females but not in males.
The authors conclude that low body weight is associated with presence
of vertebral deformity.