PREVALENCE OF FACTOR-V-LEIDEN MUTATION IN VARIOUS POPULATIONS

Resistance to activated protein C (APC) is the most common inherited r isk factor for venous thrombosis. Most cases of APC resistance are cau sed by the point mutation nt 1691 G-A in factor V gene, referred to as factor V Leiden mutation. As initially shown in a Dutch population, t his mutation has a carrier rate of 2.9%, the most frequent genetic dis position for thrombophilia and deep venous thrombosis. By large-scale epidemiological studies we have determined the prevalence of factor V Leiden mutation in populations from Poland (200), Argentina (215), Ven ezuela (126), Costa Pica (196), and India (150). The prevalences have been estimated for Poland (Warsaw) 5.0%, Argentina (Buenos Aires) 5.1% , Venezuela (Valencia) 1.6%, Costa Pica (San Jose) 2.0%, and India (Pu njab) 1.3%. Based on worldwide distribution, it can be hypothesized th at the factor V Leiden mutation has originated and accumulated in cent ral European Caucasians and spread over the world by migration. (C) 19 97 Wiiey-Liss, Inc.