DIRECT RESOLUTION OF NAPROXEN ON A NONCOVALENTLY MOLECULARLY IMPRINTED CHIRAL STATIONARY-PHASE

A synthetic polymer selective for (S)-naproxen was prepared by molecul ar imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The temp late was extracted from the polymer, leaving specific recognition site s, complementary to the template. The polymer was utilized as a statio nary phase in HPLC. Racemic naproxen was efficiently resolved on the p olymer. Furthermore, the polymer was able to separate naproxen from th e structurally related ibuprofen and ketoprofen.