NEUROTRANSMITTERS CHANGES IN MULTIPLE-SCL EROSIS

Elevated levels of norepinephrine and of excitory amino acids (glutama te, aspartate) were observed in cerebrospinal fluid of patients with m ultiple sclerosis while there were elevated content of glutamine, aspa ragine and glycine in their blood. An important point concerning these results was the relation between biochemical indices and the characte r of neurological symptoms, their severity as well as the course of th e disease. The role of neurotransmitters in pathogenesis of multiple s clerosis and particularly in biochemical mechanisms of the relation be tween nervous and immune system that underlie the development of neuro logical deficiencies is suggested.