POLYMORPHISM OF DOPAMINE-RECEPTORS AND TRANSPORTER GENES IN NEUROPSYCHIATRIC DISEASES

Authors
FUJIWARA Y YAMAGUCHI K TANAKA Y TOMITA H SHIRO Y KASHIHARA K SATO K KURODA S
Citation
Y. Fujiwara et al., POLYMORPHISM OF DOPAMINE-RECEPTORS AND TRANSPORTER GENES IN NEUROPSYCHIATRIC DISEASES, European neurology, 38, 1997, pp. 6-10
Citations number
12
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
European neurology → ACNP
ISSN journal
00143022
Volume
38
Year of publication
1997
Supplement
1
Pages
6 - 10
Database
ISI
SICI code
0014-3022(1997)38:<6:PODATG>2.0.ZU;2-A
Abstract
The advances made in studies on the molecular biology of the dopamine transporter (DAT) and receptors (D1, D2, D3, D4 and D5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric d isorders are discussed. Data from four studies on the variants of the D2 receptor gene (Ser(311)-->Cys), BalI polymorphism in D3, 48-base re peat polymorphism in D4, and 40-base repeat polymorphism in the DAT ge ne in patients with schizophrenia, mood disorder, neurological disease and controls are reported.