Jy. Pierga et al., PHASE-II TRIAL OF DOXORUBICIN, 5-FLUOROURACIL, ETOPOSIDE, AND CISPLATIN IN ADVANCED OR RECURRENT ENDOMETRIAL CARCINOMA, Gynecologic oncology, 66(2), 1997, pp. 246-249
We have previously reported an overall response rate of 41% and a medi
an survival duration of 14 months in a series of 49 patients with meta
static or recurrent endometrial carcinoma treated by a combination of
etoposide, 5-fluorouracil, and cisplatin. In order to increase respons
e rate and survival duration, doxorubicin was added to this combinatio
n. From August 1992 to January 1996, 20 consecutive patients were trea
ted with a monthly combination chemotherapy consisting of doxorubicin
30 mg/m(2) iv Day 1,5-fluorouracil 600 mg/m(2) iv Days 1 to 3, etoposi
de 80 mg/m(2) iv Days 1 to 3, and cisplatin 35 mg/m(2) iv Days 1 to 3
(AFEP). All patients were evaluable for response and toxicity. Median
age was 62 years (range 45 -72). Two to eight cycles were delivered (m
edian 5). Two of 20 patients had complete response and 7 of 20 had par
tial response. The objective response rate was 45% (CI 95%: 23-68%). T
he median survival duration was 17 months. The median progression-free
survival was 8 months. Major toxic effect was myelosuppression: 75% o
f grade 3 and 4 leukopenia and 20% of grade 3 and 4 thrombocytopenia.
Seven patients (35%) developed infection and 4 (20%) were hospitalized
once or more for toxicity. These results indicate that AFEP is an eff
ective combination therapy in metastatic endometrial carcinoma but its
toxicity is unacceptable. (C) 1997 Academic Press.