CARBOPLATIN AS RADIOSENSITIZER IN NONSMALL CELL LUNG-CANCER AFTER CISPLATIN-CONTAINING CHEMOTHERAPY - A PHASE-I STUDY OF A GROUPE FRANCAIS DE PNEUMO-CANCEROLOGIE (GFPC)

A Phase I trial of carboplatin therapy was performed on patients with locally advanced non-small cell lung cancer who had been previously tr eated with cisplatin, mitomycin and a vinca alkaloid. This was adminis tered as a daily bolus infusion or as a continuous infusion for 6 week s with concurrent daily thoracic radiation. All patients had to be obj ective responders or to show no change after chemotherapy. The carbopl atin was started at 10 mg/m(2) per day, and increased to 15 mg/m(2) pe r day and 20 mg/m(2) per day, if treatment was feasible in successive cohorts of at least six patients. The radiation therapy consisted of 6 2-66 Gray on the tumor and the ipsilateral mediastinal nodes, 50 Gray on the mediastinum and 40-45 Gray on the supraclavicular lymph nodes. Twenty-nine patients took part in this study. Thrombocytopenia was the principal dose-limiting toxicity, with 15 mg/m(2) per day of bolus or continuous infusion. Other toxicities included a fall in haemoglobin level, a fall in white-blood cell count, nausea and vomiting. The medi an survival time is 12 months, but the response rate cannot be determi ned among patients selected on the basis of response to chemotherapy. The recommended Phase II dose for patients previously treated with cis platin containing chemotherapy, is 10 mg/m(2) per day of either a bolu s or continuous infusion. (C) 1997 Elsevier Science Ireland Ltd.