ONLINE LIQUID-CHROMATOGRAPHY COUPLED WITH HIGH-FIELD NMR AND MASS-SPECTROMETRY (LC-NMR-MS) - A NEW TECHNIQUE FOR DRUG METABOLITE STRUCTURE ELUCIDATION

Authors
BURTON KI EVERETT JR NEWMAN MJ PULLEN FS RICHARDS DS SWANSON AG
Citation
Ki. Burton et al., ONLINE LIQUID-CHROMATOGRAPHY COUPLED WITH HIGH-FIELD NMR AND MASS-SPECTROMETRY (LC-NMR-MS) - A NEW TECHNIQUE FOR DRUG METABOLITE STRUCTURE ELUCIDATION, Journal of pharmaceutical and biomedical analysis, 15(12), 1997, pp. 1903-1912
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
15
Issue
12
Year of publication
1997
Pages
1903 - 1912
Database
ISI
SICI code
0731-7085(1997)15:12<1903:OLCWHN>2.0.ZU;2-O
Abstract
High performance liquid chromatography has been coupled simultaneously to high field NMR and MS detectors, giving UV, NMR and mass spectra f or each component in a mixture, after on-line separation. This powerfu l new tool for the structure elucidation of components in mixtures wit hout isolation has been successfully applied to the analysis of the me tabolites of paracetamol in human urine. (C) 1997 Elsevier Science B.V .