INTERRELATIONSHIPS BETWEEN SENSITIVITY AND SELECTIVITY MEASURES FOR SPECTROSCOPIC ANALYSIS - COMMENT

In a recent paper Kalivas and Lang state that Lorber's multivariate se nsitivity only relates to the unsealed variance inflation factor if th e number of calibration samples equals the number of analytes i.e. if pure-component spectra are used to form the response matrix. This pape r gives a proof that Lorber's multivariate sensitivity obeys the desir ed relationship under the general conditions implied by a good calibra tion design. Emphasis is placed on making a clear distinction between expected (true), observed (measured) and estimated quantities. This fa cilitates the discussion of the practical evaluation of the defining e quations and thereby solves some problems that are present in the orig inal work. The alternative definition for multivariate sensitivity pro posed by Kalivas and Lang is also discussed. (C) 1997 Elsevier Science B.V.