MOLECULAR-CLONING AND EXPRESSION OF MOUSE HOMOLOG OF SFA-1 PETA-3 (CD-151), A MEMBER OF THE TRANSMEMBRANE-4 SUPERFAMILY/

We have isolated mouse SFA-1 (CD151) cDNA from a mouse myelomonocytic leukemia cell line, WEHI-3. Mouse CD151 mRNA comprises approximately 1 .8 kb, has 253 amino acid residues with 93% identity to human CD151 an d contains four putative transmembrane domains, a number of cysteine r esidues and one potential N-glycosylation site located at a site corre sponding to that in human CD151. Mouse CD151 gene expression was obser ved in many cell types, but was either absent or present at a low leve l in brain and lymphoid cells and tissues, including thymus and spleen . The expression patterns of mouse and human CD151 genes are similar. (C) 1997 Elsevier Science B.V.