Purpose: to evaluate the role of helical CT angiography (CTA) in the d
etection of renal artery stenosis in hypertensive patients. Materials
and Methods: we studied 300 hypertensive patients (50 prospectively an
d 250 consecutively) with CTA and arteriography (n = 118). Helical acq
uisition (collimation 3 mm; pitch = 1, 20 seconds acquisition time) wa
s performed 20-45 seconds after contrast injection (300 mgl/ml; 120ml,
4ml/sec). Transverse axial views and 3D reconstructions were analyzed
(360 degrees interpolation algorithm, 1 mm overlapped). Results: in t
he prospective series, CTA sensitivity was 100% for main renal artery
stenoses and specificity was 98.2%; however 7/32 renal accessory arter
ies were not visualized. in the 300 patients studied, seventy-four ste
noses were detected. There were 5 false-positive and 5 false-negative
studies. Secondary hypertension was detected in 26% of patients (inclu
ding 14 cases of adrenal hyperplasia). Conclusion : CTA is a promising
technique for the detection of renal artery stenosis in hypertensive
patients.