AN EPITETRATHIODIOXOPIPERAZINE RELATED TO EMESTRIN FROM EMERICELLA-FOVEOLATA

An epitetrathiodioxopiperazine, secoemestrin C, related to the macrocy clic antifungal epidithiodioxopiperazine, emestrin, originally isolate d from Emericella striata and E. quadrilineata, was isolated along wit h the epitrithiodioxopiperazine, emestrin B, from the culture medium o f the early state of E. foveolata. This fungus also produced emestrin in the mycelium and dethiosecoemestrin and violaceic acid in the cultu re broth after two weeks cultivation. The structure of secoemestrin C was established by spectroscopic and chemical investigation. Secoemest rin C may be the key intermediate from emestrin and/or emestrin B to d ethiosecoemestrin. (C) 1997 Elsevier Science Ltd. All rights reserved.