EFFECTS OF THYMOSIN ALPHA-1 ON ERYTHROCYTE LIPID-LEVELS AND ERYTHROCYTE-MEMBRANE (NA-K+)-ATPASE ACTIVITY IN EXPERIMENTAL HYPERCHOLESTEROLEMIA()

Authors
GOKKUSU C ADEMOGLU E OZ H TURKOGLU UM
Citation
C. Gokkusu et al., EFFECTS OF THYMOSIN ALPHA-1 ON ERYTHROCYTE LIPID-LEVELS AND ERYTHROCYTE-MEMBRANE (NA-K+)-ATPASE ACTIVITY IN EXPERIMENTAL HYPERCHOLESTEROLEMIA(), Japanese Journal of Medical Science & Biology, 50(2), 1997, pp. 45-53
Citations number
29
Categorie Soggetti
Medicine, General & Internal
Journal title
Japanese Journal of Medical Science & Biology → ACNP
ISSN journal
00215112
Volume
50
Issue
2
Year of publication
1997
Pages
45 - 53
Database
ISI
SICI code
0021-5112(1997)50:2<45:EOTAOE>2.0.ZU;2-F
Abstract
Thymosin alpha-1 is an active polypeptide isolated from thymus. This p olypeptide is widely used in the diagnosis and treatment of many disea ses, especially immune diseases. In this present study, we examined th e effects of thymosin alpha-1 on plasma and erythrocyte lipid levels a nd the changes in erythrocyte membrane (Na+, K+)ATPase activity in hyp ercholesterolemic rabbits. The erythrocyte lipid levels decreased, whe reas the erythrocyte membrane (Na+, K+)ATPase activity increased signi ficantly in these rabbits after thymosin alpha-1 injection. These find ings suggest that thymosin alpha-1 is effective on both the lipid leve l and erythrocyte membrane (Na+, K+)ATPase activity.