THE EFFECTS OF CYCLOSPORINE-A ON THE POLYKARYOCYTE FORMATION INDUCED BY MEASLES-VIRUS IN A MONKEY KIDNEY-CELL LINE

Authors
WATARI E YOKOMURO K
Citation
E. Watari et K. Yokomuro, THE EFFECTS OF CYCLOSPORINE-A ON THE POLYKARYOCYTE FORMATION INDUCED BY MEASLES-VIRUS IN A MONKEY KIDNEY-CELL LINE, Japanese Journal of Medical Science & Biology, 50(2), 1997, pp. 79-85
Citations number
14
Categorie Soggetti
Medicine, General & Internal
Journal title
Japanese Journal of Medical Science & Biology → ACNP
ISSN journal
00215112
Volume
50
Issue
2
Year of publication
1997
Pages
79 - 85
Database
ISI
SICI code
0021-5112(1997)50:2<79:TEOCOT>2.0.ZU;2-8
Abstract
The effects of cyclosporin A (CsA) on the polykaryocyte formation indu ced by measles virus (MV) in a monkey kidney cell, line (BSC-1) were s tudied. CsA inhibited virus-induced polykaryocyte formation as well as the production of infectious MV. The development of polykaryocyte for mation in the presence of the CsA varied with virus strains, while pre treatment of the cells with 5 mu M CsA for 24 hr before the virus infe ction enhanced polykaryocyte formation. These data demonstrated that C sA not only inhibits but also enhances virus-induced polykaryocyte for mation depending on the conditions of its use.