CHRONIC TREATMENT WITH BRL-35135 POTENTIATES THE ACTION OF INSULIN ONLIPID-METABOLISM

The effects of a beta(3)-adrenoceptor agonist on insulin-induced chang es in lipid metabolism were studied in obese male Zucker (fa/fa) rats during euglycaemic clamp. Rats were treated with BRL 35135 -chlorophen yl)-ethyl-amino]-propyl]-phenoxyacetate hydrobromide) (0.5 mg/kg per d ay in drinking water) for three weeks before an euglycaemic hyperinsul inaemic clamp was performed. Insulin infusion lowered serum non-esteri fied fatty acids and plasma glycerol more efficiently in BRL 35135-tre ated than in control rats although plasma insulin remained significant ly lower in the BRL 35135-treated than in the control rats during the clamp. In conclusion, chronic treatment with BRL 35135 potentiates the effect of insulin on lipid metabolism. (C) 1997 Elsevier Science B.V.