SEQUENCES IN HYDROLYSATES OF THERMAL POLY(GLUTAMIC ACID, PHENYLALANINE, ALANINE, METHIONINE)

The four amino acids glutamic acid, phenylalanine, alanine and methion ine were polymerized by heating to a temperature of 190-200 degrees C. Non-random polymers were obtained as evidenced by Edman degradation a nd FAB mass spectrometry analysis of cyanogen bromide fragments of the polyamino acid polymers. The polymers obtained from the thermal polym erization contained pyroglutamyl N-terminal groups, as evidenced by th e lack of reaction with ninhydrin reagent. (C) 1997 Elsevier Science L td.