ALKYLATION OF AN IMIDAZOLIDINE ENAMINOESTER - A NEW SEQUENCE FOR THE C-ALPHA-ALKYLATION OF 4,5-DIHYDROIMIDAZOLES

Authors
JONES RCF PATEL P HIRST SC TURNER I
Citation
Rcf. Jones et al., ALKYLATION OF AN IMIDAZOLIDINE ENAMINOESTER - A NEW SEQUENCE FOR THE C-ALPHA-ALKYLATION OF 4,5-DIHYDROIMIDAZOLES, Tetrahedron, 53(34), 1997, pp. 11781-11790
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
34
Year of publication
1997
Pages
11781 - 11790
Database
ISI
SICI code
0040-4020(1997)53:34<11781:AOAIE->2.0.ZU;2-3
Abstract
1-Benzyl-2-(ethoxycarbonylmethylene)-2,3 undergoes preferred C-alkylat ion with halogenoalkanes, dihalogenoalkanes and epoxides: subsequent r emoval of of the ethoxycarbonyl group provides a new route to 2-alkyl- 4,5-dihydroimidazoles. 1,3-Dihalogenoalkanes afford imidazo[1,2-a]pyri dines via C,N-dialkylation. (C) 1997 Elsevier Science Ltd.