CARCINOMA OF THE INTACT UTERINE CERVIX TREATED WITH RADIOTHERAPY ALONE - A FRENCH COOPERATIVE STUDY - UPDATE AND MULTIVARIATE-ANALYSIS OF PROGNOSTICS FACTORS

Purpose: To determine independent prognostic factors in a group of 187 5 patients with invasive carcinoma of the intact uterine cervix treate d with radiotherapy alone in a French cooperative study from 1970 to 1 993, Materials and Methods: Patients were staged according to the UICC -FIGO and MDAH substaging, The distribution per FIGO stage was Ia-Ib: 25.5%; Ha: 12%; IIB: 29%; Ina: 5%; IIIb: 25%, and TV: 3.5%. Ninety-two percent had squamous cell carcinoma, The maximum diameter of the clin ically detectable cervical disease was less than 3 cm in 24.5% of Stag es I-II and in 10% of Stages III-IV, more than 5 cm in 13.5% of Stages I-II, and in 16% of Stages III-IV. Nodal involvement was shown on lym phangiogram in 16% of Stages I-LI and in 32.5% of Stages III-TV, Resul ts: Ij Univariate analysis of Stages I and II: stage, cervical disease diameter, and nodal involvement are significant prognostic factors. F ive-year specific survival rate (5ySS) is 83.5% in Stage Ib, 81% in Ha and 71% in IIb. Five-year disease-free survival rate (5yDFS) is 86% i n tumors less of 3 cm, 76% in tumors of 3 to 5 cm, and 61.5% in tumor larger than 5 cm, Lymphangiogram strongly influences the 5-year pelvic disease-free survival rate (5yPDFS): respectively, 90% in nonpositive lymphangiogram vs, 65% when positive. A significant drop in specific and disease-free survival is observed (10 and 14%, respectively (p = 0 .04) when comparing adenocarcinoma and squamous cell carcinoma, Age is a significant prognostic factor for specific survival because patient s aged less than 30 years old have 91% vs, about 75% for patients over 30 gears (p = 0.03), 2) Univariate analysis of Stages HI-IV: Stage an d positive lymphangiogram are predictive factors for relapse and death . The MDAH substaging is more reliable to predict the probability of p elvic disease-free survival in Stage III, At 5 years, the FIGO Stages IIIa and IIIb have a rather similar PDFS (65% vs, 59%), Conversely, th e difference of survival rates between MDAH Stage IIIA and Stage IIIB is more demonstrative (69% vs. 47.5%). 3) Multivariate analysis (Cox P , H. R, model), Nodal involvement and stage remain significant for all three models in all stages (p < 0.0001). Age above 70 years influence s specific survival for Stage I-II (p = 0.01). Tumors larger than 5 cm and adenocarcinoma also appear to be independent prognostic factors f or specific and disease-free survival in Stage I-II (p = 0.05 and p = 0.005, respectively). Conclusions: The relevance of tumor size (less o r greater than 4 cm) is now recognized in the 1995 revised FIGO stagin g in Stage Ib but unfortunately not in other stages, Tumor size per st age and nodal status should be systematically recorded to allow a bett er prediction of failure rates and to compare literature reports. (C) 1997 Elsevier Science Inc.