NOVEL TOCOPHEROL COMPOUNDS .10. A FACILE SYNTHESIS OF O-TRIMETHYLSILYL-5A-HALO-ALPHA-TOCOPHEROLS

Authors
ROSENAU T HABICHER WD
Citation
T. Rosenau et Wd. Habicher, NOVEL TOCOPHEROL COMPOUNDS .10. A FACILE SYNTHESIS OF O-TRIMETHYLSILYL-5A-HALO-ALPHA-TOCOPHEROLS, Tetrahedron letters, 38(34), 1997, pp. 5959-5960
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
34
Year of publication
1997
Pages
5959 - 5960
Database
ISI
SICI code
0040-4039(1997)38:34<5959:NTC.AF>2.0.ZU;2-D
Abstract
A simple and efficient procedure for the synthesis of O-trimethylsilyl -5a-bromo-alpha-tocopherol (6) and O-trimethylsilyl-5a-chloro-alpha-to copherol (7) starting from para-tocopherolquinone (5) has been develop ed. The products are formed by acid-catalyzed cyclization of para-toco pherolquinone via an ortho-quinone methide intermediate. (C) 1997 Else vier Science Ltd.