ARE ALPHA-ADRENERGIC ANTAGONISTS POTENT TOCOLYTICS - IN-VIVO EXPERIMENTS ON POSTPARTUM RATS

Citation
I. Zupko et al., ARE ALPHA-ADRENERGIC ANTAGONISTS POTENT TOCOLYTICS - IN-VIVO EXPERIMENTS ON POSTPARTUM RATS, Life sciences, 61(11), 1997, pp. 159-163
Citations number
11
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
ISSN journal
00243205
Volume
61
Issue
11
Year of publication
1997
Pages
159 - 163
Database
ISI
SICI code
0024-3205(1997)61:11<159:AAAPT->2.0.ZU;2-I
Abstract
The aim of this study was to investigate the effects of alpha-adrenerg ic antagonists on the motor activity of the postpartum uterus of the r at in vivo. Intrauterine pressure was assessed by means of a Millar ca theter fitted with a latex microballoon. Some of the tested compounds (urapidil, yohimbine, phentolamine, benoxathian and prazosin) decrease d the uterine activity to a significant extent (57.4-67.4%). However, none of the investigated alpha-receptor blockers exerted the same effe ct as beta-adrenergic agonists. Our results suggest that alpha-adrener gic antagonists could possibly be used as an alternative to beta-adren ergic agonists in clinical tocolysis after an appropriate clinical eva luation. (C) 1997 Elsevier Science Inc.