THE SYNTHESIS OF LYSINE ALPHA-KETOAMIDE THROMBIN INHIBITORS VIA AN EPOXY AMIDE RING-OPENING

Authors
CACCIOLA J ALEXANDER RS FEVIG JM STOUTEN PFW
Citation
J. Cacciola et al., THE SYNTHESIS OF LYSINE ALPHA-KETOAMIDE THROMBIN INHIBITORS VIA AN EPOXY AMIDE RING-OPENING, Tetrahedron letters, 38(33), 1997, pp. 5741-5744
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
33
Year of publication
1997
Pages
5741 - 5744
Database
ISI
SICI code
0040-4039(1997)38:33<5741:TSOLAT>2.0.ZU;2-H
Abstract
We describe a novel route for the preparation of substituted alpha-ket oamides of lysine. These compounds, due to the presence of an electrop hilic carbonyl, display submicromolar activity toward the enzyme throm bin. (C) 1997 The DuPont Merck Pharmaceutical Company.