CHEMOENZYMATIC SYNTHESIS OF GM(3), LEWIS-X AND SIALYL-LEWIS-X OLIGOSACCHARIDES IN C-13-ENRICHED FORM

Authors
PROBERT MA MILTON MJ HARRIS R SCHENKMAN S BROWN JM HOMANS SW FIELD RA
Citation
Ma. Probert et al., CHEMOENZYMATIC SYNTHESIS OF GM(3), LEWIS-X AND SIALYL-LEWIS-X OLIGOSACCHARIDES IN C-13-ENRICHED FORM, Tetrahedron letters, 38(33), 1997, pp. 5861-5864
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
33
Year of publication
1997
Pages
5861 - 5864
Database
ISI
SICI code
0040-4039(1997)38:33<5861:CSOGLA>2.0.ZU;2-E
Abstract
In connection with studies on the solution and protein-bound conformat ion of oligosaccharides, we had reason to consider the application of C-13-enriched sugars. Herein we describe the synthesis of ganglioside GM(3) trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewi s x tetrasaccharide (3) from [U-C-13]-D-Glc, [U-C-13]-L-Gal and [U-C-1 3]-pyruvate. (C) 1997 Elsevier Science Ltd.