PURPOSE: To determine the imaging features of duodenal gangliocytic pa
raganglioma that can be used to differentiate this mass from other les
ions. MATERIALS AND METHODS: Imaging, histopathologic, and surgical fi
ndings in five patients with proved gangliocytic paraganglioma were re
viewed. The most common symptom al presentation was abdominal pain (n
= 3). All patients underwent computed tomography (CT), two underwent u
ltrasonography (US), and one underwent magnetic resonance (MR) imaging
. Imaging findings were correlated with findings from surgical resecti
on specimens in all cases. RESULTS: All lesions were located around th
e second portion of the duodenum and were 3-13 cm in diameter (mean, 6
.5 cm). Two extended laterally to the duodenum, two extended medially
and one was intraluminal. All appeared solid and homogeneous on US, CT
, and MR images and had homogeneous contrast material enhancement on C
T and MR images. All were solid, with a prominent vascular network, bu
t no cystic hemorrhage or necrosis was noted at pathologic examination
. CONCLUSION: The imaging features of gangliocytic paraganglioma are s
uggestive enough for the prospective diagnosis and differentiation of
this benign mass from other lesions.