NATURAL-HISTORY OF SINGLE VENTRICLE WITH RESPECT TO ANATOMICAL AND CLINICAL FACTORS

The authors analysed the anatomical and clinical prognostic factors of single or common ventricle. This retrospective study was based on a s eries of 185 patients hospitalised between 1/2/70 and 31/12/91 in the paediatric cardiological unit of the Cardiological Hospital of Lyon wi th this condition. A number of anatomical and clinical parameters were identified in this population. For each parameter. a given patient co uld only relate to single modality and a survival graph determined by Kaplan-Meier analysis was established for each modality. For each vari able, the survival curve of the most frequently encountered modality s erved as a reference and the other modalities were compared with it us ing a logrank test. The different modalities potentially related to pa tient survival were then entered into a multivariable model using logi stic regression. The results of this study of multivariale analysis us ing the Odds-Ratio (OR) independantly suggest that four variables may influence negatively survival of patients with a single ventricle : pH less-than-or-equal-to 7.3 on admission (OR = 3.55), a non-left ventri cular morphology of the main ventricular chamber (OR = 3.11), the pres ence of an obstacle on the aortic outflow (OR = 5.58) and a total anom alous pulmonary venous drainage (OR = 26.88).