A CLINICAL-TRIAL OF BETHANECHOL IN PATIENTS WITH XEROSTOMIA AFTER RADIATION-THERAPY - A PILOT-STUDY

Authors
EPSTEIN JB BURCHELL JL EMERTON S LE ND SILVERMAN S
Citation
Jb. Epstein et al., A CLINICAL-TRIAL OF BETHANECHOL IN PATIENTS WITH XEROSTOMIA AFTER RADIATION-THERAPY - A PILOT-STUDY, Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 77(6), 1994, pp. 610-614
Citations number
39
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Journal title
Oral surgery, oral medicine, oral pathology, oral radiology and endodontics → ACNP
ISSN journal
10792104
Volume
77
Issue
6
Year of publication
1994
Pages
610 - 614
Database
ISI
SICI code
1079-2104(1994)77:6<610:ACOBIP>2.0.ZU;2-R
Abstract
The effects of bethanechol in the treatment of dry mouth were assessed in patients with xerostomia after radiation therapy to the head and n eck. Bethanechol possesses muscarinic and nicotinic-cholinergic activi ty that likely accounts for its mode of action. Bethanechol (25 mg, th ree times daily) was not associated with significant side effects. Sta tistically significant increases in whole resting saliva (p = 0.003) a nd whole stimulated saliva (p = 0.001) were seen. In patients with pre treatment stimulated saliva volumes greater than resting saliva volume s, a positive response to subsequent use of the sialagogue was seen.