STRUCTURES OF PHENOLIC GLYCOLIPIDS FROM MYCOBACTERIUM-KANSASII

From the lipid fraction of cells of Mycobacterium kansasii. four pheno lic glycolipids K5, K6, K7 and K8, were isolated, in addition to three known phenolic glycolipids KI, KII and KIV. K5 was identified as a te traglycosyl phenolic glycolipid whose sugar moiety was ha-rhamnopyrano syl(1-->3)-2,4-di-O-methyl-L-alpha- rhamnopyranosyl(1-->) and phenolic glycolipid K6 as deacetyl-KI. Glycolipids K7 and K8 were triglycosyl phenolic glycolipids having the sugar moieties of ->3)-2,4-di-O-methyl -L-alpha-rhamnopyransoyl(1-->) and l(1-->3)-2-O-methyl-L-alpha-rhamnop yranosyl(1-->), respectively. Phenolic glycolipids K6 and K7 have been referred to as controlled degradation products of phenolic glycolipid KI previously. Also isolated was -5-mycolyl-alpha-arabinofurnosyl(1-- >1')-glycerol, an analogue of glycoIipid ai, originally isolated from Mycobacterium avium-Mycobacterium intracellulare complex, having mycol ic acids of M. kansasii.