SIMULATION OF LINDANE KINETICS IN RATS

The kinetics of lindane were modelled in the male rat with a physiolog ically-based pharmacokinetic (PB-PK) model. The model was parameterize d by using reference physiological parameter values and partition coef ficients that were reported earlier in the literature. First order bio transformation and gastro-intestinal absorption constants for lindane were obtained by visually fitting the model to literature data on lind ane disposition in vivo after a single oral dose. The model was valida ted by simulating the disposition of lindane in vivo after single intr aperitoneal and chronic oral dosage and comparing simulated with exper imental results. It was concluded that the present model can adequatel y simulate most of the reported data on lindane kinetics. (C) 1997 Els evier Science Ireland Ltd.