FLUVIOLS, BICYCLIC NITROGEN-RICH ANTIBIOTICS PRODUCED BY PSEUDOMONAS-FLUORESCENS

Fifteen fluorescent pseudomonads, isolated from the rhizosphere of agr icultural plants, were similar in both their phenotypic properties and the chemical nature of produced pigments, to the previously described Pseudomonas fluorescens var. pseudoiodinum. DNA-DNA hybridisation dat a showed their genetic similarity (but not identity) to different biov ars of P. fluorescens. A family of antibiotics-fluviols belonging to p yrazolo-[4,3-e]as-triazine derivatives was isolated from studied strai ns; isolation, properties, antimicrobial and antitumour activity of fl uviols are described.