CGP 42112A ABOLISHES FACILITATION OF RECOGNITION CAUSED BY ANGIOTENSIN-II AND ANGIOTENSIN II(3-7) IN RATS

The role of the angiotensin AT(2) receptors in some behavioural effect s of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang I I(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole e ach, substantially improved object recognition memory and enhanced apo morphine (1 mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A ( 2 mu g), per se ineffective in all tests, abolished activity of both p eptides. None of the treatments significantly changed behaviour of rat s in open field. The results point to the considerable involvement of the AT(2) angiotensin receptors in the improvement of recognition memo ry caused by Ang II and Ang II(3-7).