URINARY ENDOTHELIN-1-LIKE IMMUNOREACTIVITY IN YOUNG MALE-PATIENTS WITH TESTICULAR CANCER TREATED BY CISPLATINUM - COMPARISON WITH OTHER URINARY PARAMETERS

1. Urinary excretion of endothelin-l-like immunoreactivity and urinary excretion of other parameters (gz-microglobulin, N-acetyl-beta-D-gluc osaminidase and microalbumin) were measured before, within 1 week afte r and 2 weeks after the administration of cisplatinum in five young ma le patients with testicular cancer (mean age 33.0 years) and were comp ared. 2. Urinary endothelin-l-like immunoreactivity/ creatinine during , 1 week after, and 2 weeks after cis-platinum treatment was significa ntly higher than before cis-platinum. There was no difference in urina ry endothelin-l-like immunoreactivity/creatinine during, 1 week after and 2 weeks after cis-platinum. 3. Among the four parameters, urinary endothelin-1-like immunoreactivity/creatinine showed the highest level after cis-platinum treatment. Urinary beta(2)-microglobulin/creatinin e most rapidly returned to normal levels after cc-platinum. 4. Althoug h urinary endothelin-l-like immunoreactivity/creatinine did not show a ny significant correlations with urinary N-acetyl-beta-D-glucosaminida se (r=0.291, not significant) or urinary microalbumin/creatinine (r=0. 076, not significant), it showed a significant correlation with urinar y beta(2)-microglobulin/creatinine (r=0.475, P<0.05). 5. These results suggest that endothelin-l may be a sensitive urinary parameter in det ecting cis-platinum-induced renal tubular injury.