INHIBITION OF GLYCOLYTIC-ENZYMES BY ENDOGENOUS ALDEHYDES - A POSSIBLERELATION TO DIABETIC NEUROPATHIES

Authors
NOVOTNY MV YANCEY MF STUART R WIESLER D PETERSON RG
Citation
Mv. Novotny et al., INHIBITION OF GLYCOLYTIC-ENZYMES BY ENDOGENOUS ALDEHYDES - A POSSIBLERELATION TO DIABETIC NEUROPATHIES, Biochimica et biophysica acta. Molecular basis of disease, 1226(2), 1994, pp. 145-150
Citations number
34
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular basis of disease → ACNP
ISSN journal
09254439
Volume
1226
Issue
2
Year of publication
1994
Pages
145 - 150
Database
ISI
SICI code
0925-4439(1994)1226:2<145:IOGBEA>2.0.ZU;2-E
Abstract
Endogenous saturated and unsaturated aldehydes were found in significa nt elevations in serum of diabetic humans and rats. These compounds, o riginating from the lipid peroxidation processes, are shown here to be potent inhibitors of the glycolytic enzymes, phosphofructokinase and glyceraldehyde-3-phosphate dehydrogenase. The inhibition process is no n-competitive and progressive. The aldehyde mixture, when supplemented to the standard rat diet at 1/100 ratio, caused nerve damage that is reminiscent of diabetic polyneuropathies.