STUDIES ON SYNTHESIS AND CONTROLLED-RELEA SE OF POLYMER DRUG USING LACTIC ACID-PHOSPHATE COPOLYMER AS DRUG CARRIERS

Authors
FAN CL LI B LIU ZH ZHUO RX
Citation
Cl. Fan et al., STUDIES ON SYNTHESIS AND CONTROLLED-RELEA SE OF POLYMER DRUG USING LACTIC ACID-PHOSPHATE COPOLYMER AS DRUG CARRIERS, Gaodeng xuexiao huaxue xuebao, 17(11), 1996, pp. 1788-1791
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
17
Issue
11
Year of publication
1996
Pages
1788 - 1791
Database
ISI
SICI code
0251-0790(1996)17:11<1788:SOSACS>2.0.ZU;2-K
Abstract
A kind of polymer drug, using 5-flurouril as model drug, lactic acid-p hosphate copolymers as polymer drug carriers, was synthesized. The cop olymers were characterized by H-1 NMR, IR and UV spectroscopy. The con tents of 5-fluorouril were determined by UV spectroscopy, The drug rel ease in vitro of the copolymers was studied and the influence of the c opolymer composition on the drug release in vitro was investigated.