DEVAZEPIDE ATTENUATES DL-FENFLURAMINE-INDUCED SUPPRESSION OF GASTRIC-EMPTYING BUT NOT FOOD-INTAKE IN THE 17 H FOOD-DEPRIVED RAT

Recently a number of studies have provided evidence which suggests tha t CCK and 5-HT interact in the control of food intake. The present exp eriments further examine this mechanism and the possibility that CCK a nd 5-HT interact in the control of gastric emptying. The selective CCK -A receptor antagonist, devazepide, (0.03-3.0 mg/kg) administered alon e had no intrinsic effect on gastric emptying. Devazepide (0.1 and 0.3 mg/kg) blocked dl-fenfluramine-induced (3.0 mg/kg) suppression of gas tric emptying; However, devazepide (0.03-3.0 mg/kg) failed to attenuat e the anorectic effect of the same dose of dl-fenfluramine. These resu lts suggest that under the present experimental conditions CCK and 5-H T interact in the regulation of gastric emptying but not food intake. Thus the interaction between CCK and 5-HT in the regulation of gastric emptying appears not to affect the control of ingestive behaviour. (C ) 1997 Elsevier Science Inc.