APPLICATIONS OF CAPILLARY ELECTROPHORESIS IN THE EYE-CARE PHARMACEUTICAL-INDUSTRY

The speed and resolution of capillary electrophoresis (CE), combined w ith its low cost and low volume requirements, make it a promising meth od of separating eye-care pharmaceuticals and analyzing the ionic comp osition of tears. Capillary zone electrophoresis (CZE) offers linearit y, precision, and recovery comparable to high-performance liquid chrom atography (HPLC) at a fraction of its cost. In addition, CZE separates and quantitates cocoamphocarboxyglycinate in the presence of a non-io nic fatty acid amide surfactant seven times faster than HPLC. CE easil y detects such cations as sodium and potassium in human tears.