USE OF CAPILLARY ELECTROPHORESIS FOR THE DETERMINATION OF VITAMINS OFTHE B-GROUP IN PHARMACEUTICAL PREPARATIONS

The separation of four water-soluble vitamins, i.e., thiamine, ribofla vine, pyridoxine and nicotinamide, was investigated by capillary zone electrophoresis and micellar electrokinetic chromatography. The useful ness of the internal standard technique in order to improve the precis ion of peak area when either the migration time or the injection volum e varied was demonstrated. Quantitative analyses of different pharmace utical formulations were compared with the LC method of the US Pharmac opeia. A good correlation was obtained.