CHANGES IN THE LIVER, KIDNEY AND HEART FATTY-ACID COMPOSITION FOLLOWING ADMINISTRATION OF IBUPROFEN TO MICE

Cr1:NMRI-BR male mice received 0.6 mg/day of ibuprofen (animal model f or human dose 1200 mg/day) in the diet for a period of 6 weeks. This t reatment resulted in increased body mass, liver mass, and total lipid content in the liver tissue. Changes in the fatty acid composition in the individual lipid classes were most important in kidney tissue; lev els of polyunsaturated fatty acids were increased in phospholipids and decreased in neutral lipids. These changes were compensated for by op posite changes in the levels of saturated and monoenoic acids. Similar changes were also observed in liver and heart lipids. An increased le vel of an unusual component was observed in heart tissue, which was id entified as isopropyl myristate by GC-MS and verified by comparing the mass spectra and retention times with those of synthetic standards.