A. Ainaoui et al., PROCESS OF DRUG-RELEASE WITH ORAL DOSAGE FORMS WITH A LIPIDIC GELUCIRE MATRIX, Journal of polymer engineering, 17(3), 1997, pp. 245-255
The process of drug release out of dosage forms made of the drug dispe
rsed in a lipidic Gelucire is considered. The process is based on the
following three ideas: first, the liquid dissolves the drug in contact
with it and occupies its previous place; second, the drug diffuses ou
t of the dosage form through the liquid located in it, and third, the
diffusivity of the drug varies with the concentration of the liquid in
an exponential way. These assumptions are drawn from the following ex
perimental observations: no change in dimension of the dosage form tak
es place; the amount of drug release after a long time is greater than
that evaluated with a constant diffusivity. Good agreement is obtaine
d between the kinetics of drug release obtained either by calculation
or from experiments using in vitro tests.