Sk. Sohn et al., HEPATOSPLENIC T-CELL-LYMPHOMA - PROLYMPHOCYTIC TRANSFORMATION 18 MONTHS AFTER SPLENECTOMY, International journal of hematology, 66(2), 1997, pp. 227-232
We report a young woman with pancytopenia and huge splenomegaly who wa
s also found to have peripheral T-cell lymphoma with massive infiltrat
ion of T-cells evident in the liver and spleen. A liver biopsy showed
predominant sinusoidal infiltration of pan-T cell antibody-stained T-l
ymphoid cells. Histologic examination of the spleen revealed numerous
tumor cells predominantly infiltrated in the cords and sinuses of the
red pulp, which were identical to those described in the liver. Severa
l clusters of small round abnormal cells were observed in marrow cytol
ogy. Although the patient felt well during 18 months after the splenec
tomy was done, the patient eventually manifested a huge hepatomegaly,
showed increasing white blood cell count to 42 x 10(9)/l, and numerous
prolymphocytes (66.9%) in the bone marrow. This change represented a
prolymphocytic transformation of the patient's original hepatosplenic
T-cell lymphoma. (C) 1997 Elsevier Science Ireland Ltd.