KLINEFELTER SYNDROME AND NON-HODGKIN-LYMPHOMA

Patients with a 47,XXY karyotype (Klinefelter syndrome) appear to have an increased risk of developing cancer, especially male breast cancer and germ cell tumors, but rarely malignant hematologic disorders. We report a patient with a low grade B-cell non-Hodgkin lymphoma with a 4 7,XXY karyotype in both the tumor and constitutional cells. This is on ly the 13th reported case of malignant lymphoma in a patient with Klin efelter syndrome. Although some authors postulate that the 47,XXY kary otype may be a predisposing factor in the development of hematological malignancies, the lack of reported cases suggests that such associati ons may be no more than chance findings. (C) Elsevier Science Inc., 19 97.