ISOCHROMOSOME 14Q IN REFRACTORY-ANEMIA

Trisomy 14 in hematologic disease is a rare finding and is almost excl usively associated with myeloid cell lineage. We present a case of ref ractory anemia (MDS-RA) with the uncommon features of marked elliptocy tosis and schistocytosis in the peripheral blood and isochromosome 14q . The analysis of the clinical outcome of this case and of others of m yelodysplastic (MDS)/myeloproliferative syndromes with trisomy 14 as t he sole abnormality suggests that it does not confer an unfavorable pr ognosis. (C) Elsevier Science Inc., 1997.