IDENTIFICATION OF PERICENTRIC-INVERSION-12, INV(12)(P13.1Q11), BY FLUORESCENCE IN-SITU HYBRIDIZATION IN A PATIENT WITH ACUTE MYELOID-LEUKEMIA (AML-M6)

Using probes located between 12p12.1 and 22p23.3, we performed fluores cence in situ hybridization (FISH) analysis and identified an inv(12)( p13.1q11) in a patient with acute myeloid leukemia (AML-M6). Standard cytogenetic analysis had identified the rearranged chromosome 12 as de l(12) (p11p13). Although deletions and translocations involving band 1 2p13 are fairly common chromosomal abnormalities observed in a broad s pectrum of hematologic malignancies, inv(12) is a rather rare abnormal ity. We compare the clinical and cytogenetic findings with those of th e previous cases reported in the literature. (C) Elsevier Science Inc. , 1997.