AZASULFONAMIDOPEPTIDES AS PEPTIDE-BOND HYDROLYSIS TRANSITION-STATE ANALOGS .1. SYNTHETIC APPROACHES

The title compounds, a novel class of peptide analogues in which an or -amino acid residue is replaced by a hydrazine-1,2-diyl sulfonyl group -NHNRSO(2)-, are of potential interest as proteinase inhibitors. Synt hetic approaches to such compounds and the X-ray molecular structures of two examples (16 and 28) are reported.