IMMUNOCYTOCHEMICAL STUDIES OF NEUROTROPHINS IN CEREBRAL MOTOR CORTEX IN AMYOTROPHIC-LATERAL-SCLEROSIS

Neurotrophin-like immunoreactivity was studied in post-mortem motor ce rebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) a nd controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-2 5 mu m), medium-(26-39 mu m), and large-(> 40 mu m), neurones, neurotr ophin-3 was seen in medium and small neurones, while brain-derived neu rotrophic factor was restricted to small neurones. No difference in nu mber or intensity of immunostained neurones was found between ALS and controls. (C) 1997 Elsevier Science B.V.