Rapid eye movement sleep behavior disorder may herald several neurodeg
enerative disorders associated with parkinsonism, including Parkinson'
s disease. A 72-year-old mall with a 17-year history of rapid eye move
ment sleep behavior disorder confirmed by polysomnography developed. a
progressive dementia that met operational clinical criteria for diffu
se Lewy body disease. The differential diagnosis of progressive neurod
egenerative disorders heralding as rapid eye movement sleep behavior d
isorder should now include diffuse Lewy body disease.